2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-180110
    Antiparasitic agent-32
    		Inhibitor
    Antiparasitic agent-32 (compound M9), a Piperaquine (HY-B1896) analog, is a potent P. falciparum lactate dehydrogenase (Pf LDH)-targeting antiparasitic agent (Pf3D7 IC50 = 0.40 μM). Antiparasitic agent-32 exhibits significant activity against both Pf asexual and gametocyte stages. Antiparasitic agent-32 exerts antiplasmodial activity through stable and specific noncovalent interactions at the NADH-binding site. Antiparasitic agent-32 can be used for malaria research.
    Antiparasitic agent-32
  • HY-17589BR
    Chloroquine dihydrochloride (Standard)
    		Inhibitor
    Chloroquine (dihydrochloride) (Standard) is the analytical standard of Chloroquine (dihydrochloride). This product is intended for research and analytical applications. Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].
    Chloroquine dihydrochloride (Standard)
  • HY-W714201
    Nitralin
    		Inhibitor
    Nitralin is a dinitroaniline herbicide. Nitralin exhibits inhibitory activity against Cryptosporidium parvum, with a IC50 of 4.5 µM.
    Nitralin
  • HY-111529AR
    Tafenoquine Succinate (Standard)
    		Inhibitor
    Tafenoquine (Succinate) (Standard) is the analytical standard of Tafenoquine (Succinate). This product is intended for research and analytical applications. Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent.
    Tafenoquine Succinate (Standard)
  • HY-139288
    Artemether-lumefantrine
    		Inhibitor
    Artemether-lumefantrine (Co-artemether) is an Artemisinin (HY-B0094)-derived combination antimalarial. Artemether-lumefantrine is effective against malaria caused by P. falciparum.
    Artemether-lumefantrine
  • HY-173312
    Antimalarial agent 49
    		Inhibitor
    Antimalarial agent 49 is an orally active antimalarial compound. Antimalarial agent 49 inhibits growth of Pf3D7 and PfK1 strains (IC50: 0.84 μM and 0.4 μM respectively). Antimalarial agent 49 has antimalarial activity and inhibits the development of P. berghei liver stages. Antimalarial agent 49 can be used in the study of Plasmodium infection.
    Antimalarial agent 49
  • HY-159915
    Se2h
    		Inhibitor
    Se2h is a cruzain inhibitor that exhibits strong activity against the intracellular amastigotes of Trypanosoma cruzi (EC50 < 1 μM, SI > 10), with an inhibitory activity against cruzain of IC50 < 100 nM (SI > 5.55). Compared to Benznidazole (HY-B1548) and the cruzain inhibitor K777 (HY-119293), Se2h shows superior selectivity and inhibition, while its selenazole structure reduces selenium-related toxicity. Se2h exhibits antiparasitic activity and holds promise for research in Chagas disease.
    Se2h
  • HY-175974
    Antitrypanosomal agent 27
    		Inhibitor
    Antitrypanosomal agent 27 (Compound 5c) is a quinazoline compound with antitrypanosomal activity. Antitrypanosomal agent 27 inhibits T.b. brucei with a GI50 of 31 nM. Antitrypanosomal agent 27 can be used for the research of human african trypanosomiasis.
    Antitrypanosomal agent 27
  • HY-B1194R
    Tetramisole hydrochloride (Standard)
    		Inhibitor
    Tetramisole hydrochloride (Standard) is the analytical standard of Tetramisole (hydrochloride). This product is intended for research and analytical applications. Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure.
    Tetramisole hydrochloride (Standard)
  • HY-14895AR
    Fabomotizole hydrochloride (Standard)
    		Inhibitor
    Fabomotizole (hydrochloride) (Standard) is the analytical standard of Fabomotizole (hydrochloride). This product is intended for research and analytical applications. Fabomotizole (CM346) hydrochloride is a compound with anxiolytic and neuroprotective activities. Fabomotizole (CM346) hydrochloride also has activity against Giardia lamblia and has the potential to inhibit giardiasis.
    Fabomotizole hydrochloride (Standard)
  • HY-116552
    KAR425
    		Inhibitor
    KAR425 is a potent and orally active antimalarial agent. KAR425 shows antimalarial activity against the Chloroquine-sensitive (CQS) D6, the Chloroquine-resistant (CQR) Dd2, and 7G8 strains of Plasmodium falciparum, with IC50 values of 62 nM, 55 nM, and 60 nM, respectively.
    KAR425
  • HY-163804
    Cyprocide-B
    		Inhibitor
    Cyprocide-B is activated by Cytochrome P450 and converted to electrophilic metabolites that selectively kill nematodes C. elegans. Cyprocide-B is promising for research of selective nematicide.
    Cyprocide-B
  • HY-180352
    Antiparasitic agent-37
    		Inhibitor
    Antiparasitic agent-37 (Compound 4717) is an orally active antiparasitic agent. Antiparasitic agent-37 exhibits activity against S. mansoni in mice. Antiparasitic agent-37 has an oral LD50 of 0.4 g/kg in mice after a single dose. Antiparasitic agent-37 can be used for the research of infectious diseases.
    Antiparasitic agent-37
  • HY-173461
    Anti-Trypanosoma cruzi agent-7
    		Inhibitor
    Anti-Trypanosoma cruzi agent-7 (compound 1) is a potent Trypanosoma cruzi inhibitor with an EC50 of 1.26 µM. Anti-Trypanosoma cruzi agent-7 can be used in the study of Chagas disease.
    Anti-Trypanosoma cruzi agent-7
  • HY-128214
    IMPDH-IN-3
    		Inhibitor
    IMPDH-IN-3 (Compound C67) is an inhibitor of C. parvum IMPDH (CpIMPDH) with an IC50 of 35 nM. IMPDH-IN-3 can be used in the research of anti-Cryptosporidium drugs.
    IMPDH-IN-3
  • HY-N15096
    Milbemycin α14
    		Inhibitor
    Milbemycin α14 is an antibiotic and has the effect of killing nematodes and mites.
    Milbemycin α14
  • HY-181437
    Antiparasitic agent-40
    		Inhibitor
    Antiparasitic agent-40 (compound 4.3) is a 4-thiazolidinone-based antileishmaniasis inhibitor. Antiparasitic agent-40 exhibits significant inhibitory activity against methionine aminopeptidase.
    Antiparasitic agent-40
  • HY-N1451R
    Betulonic acid (Standard)
    		Inhibitor
    Betulonic acid (Standard) is the analytical standard of Betulonic acid. This product is intended for research and analytical applications. Betulonic acid (Betunolic acid), a naturally occurring triterpene, is found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, antiparasitic and anti-viral (HSV-1) activities.
    Betulonic acid (Standard)
  • HY-123746
    E5700
    		Inhibitor
    E5700 is an orally active squalene synthase inhibitor, antimalarial agent and antifungal agent with an IC50 of 0.49 nM (without PPi) against squalene synthase from T. cruzi epimastigotes. E5700 shows antiparasitic activities against Trypanosoma cruzi. E5700 inhibits the growth and alters the lipid prolife and the ultrastructure of a multiple agent-resistant C. tropicalis strain. E5700 is a potent and selective inhibitor of the growth of Leishmania amazonensis.
    E5700
  • HY-12724AR
    Guanabenz hydrochloride (Standard)
    		Inhibitor
    Guanabenz (hydrochloride) (Standard) is the analytical standard of Guanabenz (hydrochloride). This product is intended for research and analytical applications. Guanabenz hydrochloride is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure.
    Guanabenz hydrochloride (Standard)
Parasite Isoform Comparison

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